bedtools: a powerful toolset for genome arithmetic
http://bedtools.readthedocs.io/en/latest/#
bedtools allows one to intersect, merge, count, complement, and shuffle genomic intervals from multiple files in widely-used genomic file formats such as BAM, BED, GFF/GTF, VCF. While each individual tool is designed to do a relatively simple task (e.g., intersect two interval files), quite sophisticated analyses can be conducted by combining multiple bedtools operations on the UNIX command line.
BEDOPS: the fast, highly scalable and easily-parallelizable genome analysis toolkit¶
https://bedops.readthedocs.io/en/latest/index.html
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